翻訳と辞書 Words near each other ・ Leucozonia triserialis ・ Leucozonia tuberculata ・ Leucrocuta ・ Leucrotta (Dungeons & Dragons) ・ Leuctra ・ Leuctridae ・ Leuctrides ・ Leucula ・ Leuculodes ・ Leuculodes lacteolaria ・ Leuculodes lephassa ・ Leuculopsis ・ Leucus ・ Leucuș River ・ Leucușești ・ Leucyl aminopeptidase ・ Leucyl endopeptidase ・ Leucyl-tRNA synthetase ・ Leucyl/cystinyl aminopeptidase ・ Leucyltransferase ・ Leuda-May Historic District ・ Leudal ・ Leudelange ・ Leudelange railway station ・ Leudelsbach ・ Leudeniya ・ Leudesius ・ Leudeville ・ Leudinus ・ Leudon-en-Brie Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Leucyl aminopeptidase ： ウィキペディア英語版 Leucyl aminopeptidase Leucyl aminopeptidases (, ''leucine aminopeptidase'', ''LAPs'', ''leucyl peptidase'', ''peptidase S'', ''cytosol aminopeptidase'', ''cathepsin III'', ''L-leucine aminopeptidase'', ''leucinaminopeptidase'', ''leucinamide aminopeptidase'', ''FTBL proteins'', ''proteinates FTBL'', ''aminopeptidase II'', ''aminopeptidase III'', ''aminopeptidase I'') are enzymes that preferentially catalyze the hydrolysis of leucine residues at the N-terminus of peptides and proteins. Other N-terminal residues can also be cleaved, however. LAPs have been found across superkingdoms. Identified LAPs include human LAP, bovine lens LAP, porcine LAP, ''Escherichia coli'' (''E. coli'') LAP (also known as PepA or XerB), and the solanaceous-specific acidic LAP (LAP-A) in tomato (''Solanum lycopersicum''). ==Enzyme Description, Structure, and Active Site== The active sites in PepA and in bovine lens LAP have been found to be similar. Shown in the picture below is the proposed model for the active site of LAP-A in tomato based on the work of Strater ''et al''. It is also known that the biochemistry of the LAPs from these three kingdoms is very similar. PepA, bovine lens LAP, and LAP-A preferentially cleave N-terminal leucine, arginine, and methionine residues. These enzymes are all metallopeptidases requiring divalent metal cations for their enzymatic activity Enzymes are active in the presence of Mn+2, Mg+2 and Zn+2. These enzymes are also known to have high pH (pH 8) and temperature optima. At pH 8, the highest enzymatic activity is seen at 60 °C. PepA, bovine lens LAP and LAP-A are also known to form hexamers ''in vivo''. The Gu et al. from 1999 demonstrated that six 55kDA enzymatically inactive LAP-A protomers come together to form the 353kDa bioactive LAP-A hexamer. Structures of the bovine lens LAP protomer and the biologically active hexamer have been constructed can be found through Protein Data Bank (2J9A). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Leucyl aminopeptidase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.